The best states to start a small business in 2026 are Wyoming, South Dakota and North Dakota, but the worst state may surprise you. California ranks dead last despite its tech reputation, while Great Plains states lead our rankings.
Your location choice could determine whether your business survives or fails. Wyoming leads with a composite score of 68.98 and the nation's best tax climate. California ranks #51 with a score of 29.73, dragged down by the worst cost structure in America, a 39-point gap separating best from worst.
For a small business earning $500,000 annually with 10% margins, that gap translates to $12,000-$15,000 in annual cost differences. That's money that could fund hiring, marketing or emergency reserves.
Whether you're launching a small business in a business-friendly climate or navigating a high-cost environment, location choices have lasting financial impacts.

